hit counter

Facial Palsy Telerehabilitation Reduced Anxiety in 16-Patient Pilot

MHD featured image for facial palsy telerehabilitation and anxiety reduction.

A 16-patient pilot study after facial reanimation surgery found that online emotional training and in-person emotional training both reduced anxiety and improved facial movement; FDI physical function changed by 21.25 points in the in-person group vs. 7.5 points in the online group.1 Research Highlights Small pilot, real recovery signal: Guidetti et al. followed 16 adults …

Read more

Language and Theory of Mind Separate by Age 3 in Child Brain Scans

MHD featured image for language and theory of mind brain development in children.

A 2026 fMRI study found language and theory-of-mind activation already separated in 54 child sessions from ages 3-9, with strict child overlap near zero in the left superior temporal lobe (Dice 0.015) and no evidence that the 2 systems disentangled with age.1 The result pushes against a simple developmental story in which language grows out …

Read more

LIFU vs. rTMS for Stroke Recovery: Same 2-Week Endpoint, Larger FMA Gains

MHD featured image for LIFU vs. rTMS in post-stroke motor recovery.

A 2026 secondary randomized-trial analysis found that low-intensity focused ultrasound and repetitive transcranial magnetic stimulation reached statistically similar 2-week post-treatment motor scores after subacute stroke, even though LIFU produced larger median Fugl–Meyer Assessment gains than rTMS: 7 vs. 2 upper-limb points and 3 vs. 1 lower-limb points.1 LIFU therefore carries the recovery-dynamics signal in this …

Read more

Levetiracetam Range in Children: 2.82-24.37 mcg/mL TDM

MHD featured image for levetiracetam therapeutic drug monitoring in children with epilepsy.

A 2026 real-world study involving 1,174 children with epilepsy proposed a levetiracetam therapeutic drug monitoring range of 2.82-24.37 mcg/mL, much lower than commonly cited adult-style ranges, but the same data also warned against treating a drug level as a stand-alone seizure-control predictor. Research Highlights Lower pediatric range: Sun et al. proposed an observational levetiracetam range …

Read more

Autoimmune Focal Epilepsy: Antibody Testing and Immunotherapy

MHD featured image for autoimmune drug-resistant focal epilepsy and immunotherapy.

A 2026 structured review of autoimmune drug-resistant focal epilepsy argues for a narrow but clinically important claim: immune mechanisms can make seizures refractory in selected patients, but the evidence supports targeted testing and immunotherapy triage rather than treating every medication-resistant seizure disorder as autoimmune. Research Highlights Autoimmune epilepsy is a subset: Kunecki et al. estimated …

Read more

Multiple Sclerosis Iron MRI Linked to Cognitive Impairment in 12 Studies

MHD featured image for multiple sclerosis, iron-sensitive MRI, and cognitive impairment.

A 2026 systematic review of advanced neuroimaging in multiple sclerosis narrowed 600 database records to 12 studies and found the clearest cognition signal in basal ganglia iron-sensitive MRI measures, while thalamic susceptibility was more variable and often tangled with atrophy. Research Highlights Basal ganglia signal was strongest: across 12 studies, elevated susceptibility or iron-related metrics …

Read more

Tau Oligomers Disrupted Nuclear Lamina in Alzheimer’s Disease Models

MHD featured image for tau oligomers, nuclear lamina disruption, and Alzheimer's disease models.

A 2026 Acta Neuropathologica study found that oligomeric tau was linked to early nuclear lamina disruption in Alzheimer’s disease tissue, PS19 tauopathy mice, and human induced pluripotent stem cell (iPSC)-derived neurons.1 The strongest claim is mechanistic: tau oligomers appeared to deform the nuclear envelope and disturb chromatin before overt neurodegeneration, but the work does not …

Read more