Psilocybin for Depression, MDMA for PTSD: What Phase 3 Trials Show
Media coverage of psychedelics outpaces the trial evidence. MDMA-PTSD signals are large; psilocybin-depression effects shrink against active comparators.
Depression
Parental Mental Illness vs. Offspring Cognition: Schizophrenia, Bipolar, Depression
A 1.6M-participant meta-analysis shows a clear gradient: parental schizophrenia hits offspring cognition harder than bipolar, which hits harder than MDD.
How Much Does Loneliness Raise Dementia and Suicide Risk?
Loneliness raises measured risk of Alzheimer’s, suicidal ideation, and completed suicide. The associations are documented; the precise magnitudes are not.
When Inflammation Drives Depression — and When It Doesn’t
‘Depression is inflammation’ holds for a subgroup of patients, not for everyone. Community-sample and twin data weaken the broader version of the claim.
ECT: A Modern Reappraisal of Suicide, Dementia, and Mortality
Modern administrative cohorts find no dementia signal for ECT and link it to lower suicide and mortality. The supportive literature carries known biases worth flagging.
Exercise for Depression and Anxiety: 2025 Evidence Synthesis
Exercise reliably reduces depression and anxiety symptoms — but the cardio-vs-resistance gap and antidepressant parity claims are overstated.
Sex Differences of Gut Bacteria (Microbiome) in Major Depression (2024 Review)
The intricate relationship between the gut microbiome and major depressive disorder (MDD) is gaining significant attention within the scientific community. Emerging research highlights sex-specific disparities in the gut microbiome’s composition and its potential impact on MDD, pointing towards the necessity of integrating sex as a biological variable in future studies. Highlights: Sex Disparities in MDD: …