Mental Health DailyResearch. Evidence. Perspective.Published research on treatment-resistant schizophrenia.
A 2026 case report describes a man in his 30s with autism, childhood temporal lobe epilepsy and treatment-resistant schizophrenia whose delusions center on fictional media characters. Clozap…
Read articleA 2026 case report from Japan describes a woman in her 50s with treatment-resistant schizophrenia who was diagnosed with multiple sclerosis 31 years after her psychosis began. MS treatment s…
Read articleA 2026 nationwide study in Japan found that 28.6% of hospitalized patients with schizophrenia who were checked for treatment resistance met the criteria.1 Nearly half of those patients left …
Read articleA 2026 case report described valproate 800 mg/day improving agitation in residual-phase treatment-resistant schizophrenia but being followed by hypoglycemia and pancytopenia; after discontin…
Read articleClozapine has been the most effective antipsychotic in schizophrenia for almost 40 years, yet it is still routinely held back until patients have failed multiple alternatives over many years…
Read articleClozapine is the only medication with proven efficacy for treatment-resistant schizophrenia, yet most eligible patients wait years before starting it. A 2026 paper by Perfalk and colleagues …
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