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Gabapentin Plus Hegu Embedding: 92% Postherpetic Neuralgia Response

MHD featured image for gabapentin, Hegu catgut embedding, postherpetic neuralgia, and sleep quality.

A 210-person randomized assessor-blinded trial found that adding weekly Hegu-point catgut embedding to gabapentin improved 4-week postherpetic-neuralgia response from 80.00% to 92.38%; compared with gabapentin alone, the add-on arm also ended with lower sleep-problem scores and fewer adverse events.[1] This 2026 trial supports an add-on signal that still needs sham-controlled confirmation because follow-up lasted only …

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Adult ADHD Linked to Lower SIRT-1/Nrf-2/HO-1 Antioxidant Defenses

MHD featured image for adult ADHD, SIRT-1, Nrf-2, HO-1, and antioxidant-defense biomarkers.

A 2026 case-control study found that treatment-naive adults with attention-deficit/hyperactivity disorder (ADHD) had much lower serum SIRT-1, Nrf-2, and HO-1 than matched controls, while TNF-α did not differ. The pattern points more toward impaired antioxidant-defense regulation than a simple broad-inflammation story. Research Highlights Antioxidant-defense markers were lower: adults with ADHD had lower SIRT-1 (9.36 vs. …

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Twin Study Finds No Broad Cytokine Link to Depression or Alcohol Use Disorder

Photoreal illustration of cytokine molecules and brain imagery, conveying inflammation-depression hypothesis under scrutiny.

The broad cytokine story failed its most direct community test: in 972 adults, depression, alcohol use, and alcohol use disorder (AUD) were not associated with C-reactive protein (CRP) or a pre-registered pro-inflammatory cytokine index. The only multiple-testing-corrected cytokine hits ran opposite the hypothesis — AUD was linked to lower IL-1β, IL-4, IL-10, and IL-12 — …

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