A 2026 Add Health analysis found that combining major-depression and alcohol-use-disorder polygenic scores added 4.88% variance for comorbid MDD-AUD prediction, while same-trait scores added only 0.65% for MDD and 1.52% for AUD alone.1 The genetic signal is strongest where the clinical problem is hardest: depression plus alcohol-use disorder, not either diagnosis in isolation. Research Highlights …
A 2025 paper by Gu et al. in Molecular Psychiatry — the largest study of its kind — finds that higher common-variant genetic risk for autism predicts lower cortical neurite density in 31,748 UK Biobank adults and 4,928 ABCD children.1 The effect is small in absolute terms but replicates across cohorts and methods. Research Highlights …
A 2026 TwinLife analysis found that cognitive ability at age 23 predicted education and occupational status at age 27, and bivariate twin models attributed 69-98% of the shared IQ–SES variance to genetic factors rather than unique environment.1 The calibrated reading is narrow but important: the finding argues against treating cognition, schooling, and occupation as purely …