PTSD symptom scores fell by about half among 94 US servicemembers who completed a 4-week program of EEG-guided magnetic brain stimulation, according to a 2026 chart review. The program had no control group, so the study cannot show how much of that drop came from the treatment itself.1 Research Highlights PTSD scores dropped 48%: average …
A 2026 ANTLER mechanistic analysis found no evidence that maintaining antidepressants preserved a happier facial-emotion recognition pattern compared with placebo substitution at 12 weeks (adjusted mean difference 0.23, 95% CI −0.5 to 1.0, p = 0.5) or 52 weeks (0.29, 95% CI −0.5 to 1.2, p = 0.5). Research Highlights No 12-week maintenance advantage: discontinuation …
A 147-person feasibility randomized trial found that both a structured AI therapy chatbot and general ChatGPT reduced PHQ-9 depression scores compared with assessment-only control, with effect sizes of d = −0.47 and d = −0.44.1 The purpose-built therapy bot did not significantly outperform ChatGPT on depression, anxiety, impairment, or wellbeing. Research Highlights Both chatbots reduced …
A 2026 NHANES analysis of 6,502 adults found that urinary 3-PBA, a pyrethroid insecticide metabolite, was modestly associated with depression risk at OR = 1.02 per 1 μg/L, while self-reported household pesticide exposure weakened after full adjustment to OR = 1.43 (95% CI 0.91 to 2.25).1 The calibrated read is biomarker signal first, causal language …
A 2026 NHANES mortality analysis found that adults with PHQ-9 depressive symptoms had lower long-term all-cause mortality when their CALLY index was higher: in the fully adjusted model, each 1-unit higher log-CALLY value carried a hazard ratio of 0.59, with a 95% confidence interval from 0.51 to 0.68.1 The useful interpretation is prognostic, not therapeutic: …
A 2026 participatory-design and case-study paper turned smartphone mental-health data into 6 clinician-facing visualizations for an 8-week anxiety/depression digital clinic, using feedback from 15 clinicians and 3 clinical supervisors. The useful claim is workflow-level: charts made passive sensing and symptom ratings discussable inside care, but the paper did not test whether the visualizations improved clinical …
A 12-week randomized pilot trial in 60 Veterans with depression and psychiatric polypharmacy found that 30% had an actionable antidepressant gene-drug interaction, but immediate access to pharmacogenomic results did not clearly change prescribing or Patient Health Questionnaire-9 depression scores compared with delayed access.1 Research Highlights Actionable PGx results were common: 18 of 60 Veterans, or …