A 2026 immunopsychiatry cohort study found that soluble CD27 (sCD27), a marker of T-cell activation, was positive in cerebrospinal fluid in 23% of severe psychiatric patients selected for suspected immune involvement and in 88% of multiple sclerosis patients used as a positive-control group. In the psychiatric cohort, combined cerebrospinal fluid or blood sCD27 positivity was …
Parenteral clomipramine has a strong clinical myth around it: bypass the gut, raise parent-drug exposure quickly, and maybe accelerate rescue in severe depression or OCD. A 2026 systematic review found the route advantage was not clearly proven: in depression, 5 RCTs without high risk of bias did not show clear IV or IM superiority over …
Obsessive-Compulsive Disorder (OCD) in adolescents is a challenging condition, marked by intrusive thoughts and compulsive behaviors that significantly impair daily functioning. Recent studies have spotlighted the Bergen 4-Day Treatment (B4DT), an intensive, concentrated therapy approach showing promising outcomes in treating adolescents with OCD across various sites in Norway. This innovative method, comprising prolonged sessions of …
Obsessive-compulsive disorder (OCD) is more than a mental health issue; it’s a condition that can influence the physical health and lifestyle habits of those it affects. A recent international survey shed light on the intricate relationship between OCD and various health-related issues, highlighting the importance of addressing lifestyle habits alongside mental health treatment. By exploring …
In the relentless pursuit of effective treatments for mental disorders, neurosurgery offers a glimmer of hope where traditional methods falter. Bilateral anterior capsulotomy (BAC), a neurosurgical procedure, emerges as an option for patients with treatment-resistant depression (TRD) and obsessive-compulsive disorder (OCD), offering substantial relief with minimal side effects. Highlights: Bilateral Anterior Capsulotomy (BAC) is a …
Obsessive-compulsive disorder (OCD), a prevalent neuropsychiatric condition, presents significant treatment challenges due to its varied symptom patterns and poor response to traditional medications. Recent research has revealed a novel approach to treating OCD, focusing on the interplay between dopamine D2 receptor (D2R) agonists and proton pump inhibitors (PPIs). Highlights: OCD’s Complex Treatment Landscape: Traditional treatments …
Hyperglycemia, or high blood sugar, is more than a mere symptom of diabetes; it’s a complex condition that may significantly impact cognitive functions like memory and attention. While the association between diabetes and physical health complications is well known, there’s a growing body of research exploring how altered insulin signaling, a key feature of diabetes, …