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Top-Ranked Treatments for Schizophrenia Aggression: Clozapine, Paliperidone and Olanzapine

MHD card with an amber network of antipsychotic drug nodes linked to a placebo node over a dark background, with a calming waveform: clozapine, paliperidone, and olanzapine reduced aggression in schizophrenia most, but confidence was low.

A 2026 analysis of 41 randomized studies involving 21,025 adults with schizophrenia found the largest estimated reductions in hostility and aggression for clozapine (standardized mean difference, or SMD, of −0.75), paliperidone (−0.62), and olanzapine (−0.60) vs. placebo.1 Confidence in every comparison was low or very low, the top 3 were not statistically separable, and most …

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Exercise for Cancer Fatigue: Yoga Leads, Aerobic Training Improves QoL

MHD featured image for exercise interventions in cancer survivorship symptoms.

A 2026 network meta-analysis of 57 randomized trials involving 5,675 cancer survivors found that exercise helped several survivorship symptoms, but the strongest signal depended on the symptom: mind-body exercise ranked highest for cancer-related fatigue, aerobic training ranked highest for health-related quality of life, and combined aerobic plus resistance training led physical-function outcomes.1 Research Highlights Fatigue …

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GLP-1 Drugs for Parkinson’s: Lixisenatide Signal, Exenatide Miss

Stylized illustration representing GLP-1 receptor agonists being investigated as potential disease-modifying treatments for Parkinson's disease.

Parkinson’s disease is the second most common neurodegenerative disorder, affecting around 10 million people worldwide. The mental-health burden is heavy: depression affects 40-50% of patients9, anxiety 30-40%, sleep disorders most patients eventually, and dementia about a third of long-duration cases. Standard treatment with levodopa controls motor symptoms but doesn’t slow the underlying neurodegeneration. The clinical …

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