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inflammation

NLRP3 Inflammasome & Depression: A Target for Antidepressant Development?

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The NLRP3 inflammasome stands at the crossroads of immune response and mental health, playing a pivotal role in the inflammatory processes implicated in depression. Researchers are exploring the intricate relationship between NLRP3 activation and depressive disorders, highlighting the potential for innovative treatments targeting this complex molecular pathway. Highlights: NLRP3 Inflammasome Activation: NLRP3, a component of …

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Mycobacterium vaccae Vaccine: A Novel Soil Bacteria-Based Treatment for Anxiety & Stress Disorders

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Stress can induce anxiety and depression, which appears to be mediated in part by stress-induced neuroinflammatory processes. The immunoregulatory bacterium Mycobacterium vaccae (M. vaccae) has anti-inflammatory and stress-resilient effects, but its impact on the brain is unclear. A study discovered that M. vaccae immunization: induces anti-inflammatory and immunoregulatory processes in the hippocampus, blocks stress-induced neuroinflammation …

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High Remnant Cholesterol Levels Linked to Depression Risk in U.S. Adults

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Remnant cholesterol (RC), also known as triglyceride-rich lipoproteins, has been gaining increasing attention in recent years due to evidence linking it to cardiovascular disease, diabetes, chronic kidney disease, and other conditions. A new study suggests that elevated levels of remnant cholesterol in the blood may be associated with an increased risk of depression. Key Facts: …

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Adjunct Celecoxib for Depression & Mania: Treatment with a COX-2 Inhibitor

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Celecoxib, a selective COX-2 inhibitor, shows promise as an effective and safe adjunct treatment for major depression and mania, according to a new comprehensive systematic review. The analysis also found celecoxib improved symptoms when used as a standalone antidepressant in patients with somatic disorders. However, evidence for efficacy in bipolar depression remains unclear. Key Facts: …

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Kybella (Deoxycholic Acid) Side Effects & Adverse Reactions (List)

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Kybella (Deoxycholic acid) is an injectable medication engineered by Kythera Biopharmaceuticals and approved by the FDA in April 2015 for the management of moderate-to-severe submental fat (fat beneath the chin) in adults.  Reducing the appearance of a protruding “double chin” with Kybella entails visiting a medical professional to receive a series of subcutaneous [deoxycholic acid] …

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Whole-Body Hyperthermia For Depression: Turning Up The Heat To Enhance Mood?

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Hyperthermia is defined as supraphysiological body temperature resulting from absorption and/or production of more heat than is dispelled.  Medically, local hyperthermia is often used as an adjunct to radiation and/or chemotherapy for the treatment of cancers.  It is thought that deliberate induction of hyperthermia to a cancerous region of the body increases the sensitivity of …

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