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APOE

Alzheimer’s RVI-AD MRI Score Predicted Dementia Conversion With 0.70 AUC

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A 2026 Molecular Psychiatry study found that RVI-AD, a structural-MRI score measuring how closely a person’s brain anatomy matches an Alzheimer’s disease pattern, predicted mild-cognitive-impairment conversion to dementia most strongly over the next 3 years: OR 2.16, 95% CI 1.81-2.57, p < 2e-16, AUC 0.70.1 Research Highlights Short-term conversion signal: in 965 ADNI participants with …

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Plasma p-tau217 Blood Test Predicts Alzheimer’s Risk 1.5x Stronger in APOE-e4

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Photoreal illustration representing a blood biomarker test for Alzheimer's disease with imagery of blood vials, neurons, and APOE genetic motifs.

Until recently, Alzheimer’s pathology could only be confirmed in living patients via PET imaging or lumbar puncture. Plasma p-tau217 changed that calculus — but how to interpret a positive result depends substantially on APOE genotype.1 Research Highlights Plasma p-tau217 is a blood biomarker that rises years before Alzheimer’s symptoms. The 2024 Alzheimer’s Association revised criteria …

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