Mental Health DailyResearch. Evidence. Perspective.Published research on alzheimers disease.
A 2026 Nature Neuroscience study from the Igarashi lab proposes a circuit-level answer for why the lateral entorhinal cortex (LEC) is the first cortical region to falter in Alzheimer’s: dopa…
Read articleDementia rates in the US, UK, Netherlands, Sweden, France, and several other high-income countries have been falling for decades, despite population aging. The standard explanation — improve…
Read articleA 2026 medRxiv meta-analysis of 27 trials found that transcranial direct current stimulation added to cognitive training improved global cognition immediately after treatment by SMD 0.36 com…
Read articleA preprint in 84 older adults with epilepsy found that abnormal Alzheimer's-related blood biomarkers were common, but the biomarker categories did not line up neatly with cognitive impairmen…
Read articleA 2026 review argues that neurovascular-unit dysfunction may precede amyloid-beta generation in Alzheimer’s disease and then synergize with amyloid deposition, tau pathology, inflammation, a…
Read articleA 2026 medicinal-chemistry study found that thymol carbamate TC-6 inhibited human butyrylcholinesterase at 3.6 nM, showed more than 2,500-fold selectivity over human acetylcholinesterase, cr…
Read articleA 2026 ADNI/A4 validation study found that Alzheimer’s plasma-biomarker machine-learning models still ranked amyloid PET status well across cohorts, but the practical rule-out number moved h…
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