A 2026 Nature Neuroscience study found that lecanemab cleared amyloid in a humanized-microglia Alzheimer’s disease model only when microglia and the antibody’s intact Fc fragment were both present: X-34 plaque area differed across IgG1, lecanemab, and Fc-silenced LALA-PG groups (P = 0.0003), 82E1 plaque area differed across groups (P < 0.0001), and microglia-deficient mice showed …
A 2026 total-body tau-PET study of 28 people with Alzheimer’s disease and 23 biomarker-negative controls found stronger brain-organ network connectivity in Alzheimer’s disease than in biomarker-negative controls: 35 altered connections, including 21 brain-body edges, plus AD-only links between brain-organ coupling, cortical tau burden, MRI-derived glymphatic markers, and cognition.1 The result is best read as a …
A 2026 two-cohort connectome study found that post-stroke depressive symptoms tracked damage to networks weighted by the serotonin transporter and vesicular acetylcholine transporter: 5-HTT damage predicted depression in Leipzig (OR 2.4, 95% CI 1.15–5.02) and Oxford (OR 2.05, 95% CI 1.03–4.09), while VAChT damage also replicated across both cohorts.1 The dopamine part of the original …
A 2026 RNA-seq analysis of 1,711 autistic probands found 3 gene-expression clusters: 425 people with more severe restricted and repetitive behaviors than the other clusters, 282 with milder symptoms and better adaptive function than the other clusters, and 1,004 with stronger social-communication impairment than the other clusters.1 The supported claim is molecular stratification, not a …
A 2026 fMRI study of 1,006 healthy young adults found that emotional pictures were remembered better than neutral pictures, but the brain signal split after arousal was modeled: amygdala and insula effects dropped out, while negative and positive valence kept separate cortical encoding patterns.1 Research Highlights Emotional pictures had the recall advantage: in the full …
A 2026 eLife study recorded 3,881 lateral orbitofrontal cortex units in rats and found that prior cocaine use made the OFC over-distinguish task positions that controls treated as functionally equivalent. The headline result was not gross task failure: cocaine-experienced rats still performed the odor task, but their OFC ensembles showed higher S1-vs.-S2 decoding than sucrose …
A 2026 longitudinal MRI preprint involving 54 people with Friedreich ataxia and 57 controls found 3 biologically interpretable progression subtypes: microstructure-dominant, macrostructure-dominant, and minimal/no progression.1 The clusters make biomarker heterogeneity visible at the research level, while the classifier remains too early to assign individual patients to treatment paths. Research Highlights 3 MRI progression subtypes emerged: …