An Ethiopian umbrella review estimated perinatal depressive symptoms at 22.49% across 8 systematic reviews and meta-analyses. Antenatal and postnatal rates were similar, so the burden spans the whole perinatal window rather than clustering only after delivery.1 Research Highlights Overall pooled prevalence was 22.49%: Necho et al. combined 8 Ethiopian systematic reviews and meta-analyses covering 28 …
A 2026 medRxiv preprint used 68 NeuroMark SPECT components to analyze 2,746 psychiatric patient scans and 76 controls, linking depression-related worry/rumination and social disinterest to brain-network patterns.1 This preprint is useful as a large biomarker-generating map, but the clinical-diagnostic claim needs much more caution than the sample size alone suggests. Research Highlights Large clinical SPECT …
In 433 non-demented amyotrophic lateral sclerosis (ALS) patients, clinically significant anxiety was present in 18.2% for state anxiety and 13.9% for trait anxiety. The strongest predictor was not motor severity, cognition, or caregiver-rated behavior; it was depression, especially cognitive-affective depression symptoms.1 Research Highlights ALS anxiety was measurable but not universal: Aiello et al. found clinically …
Chronic stress is a candidate mechanism for both depression and addiction risk. A 2026 mouse study found that 28 days of unpredictable chronic mild stress increased striatal dopamine D1 receptor binding by 22–48% across nearly every region examined, plus more selective D2 receptor increases — pointing to a stress-driven shift in reward signaling that may …
An 11-person case series tested delayed-release apple cider vinegar capsules in young adults who had gained weight while taking psychotropic medications, and metabolic markers carried more signal than weight loss. Research Highlights Feasibility was the strongest result: 11 of 12 enrolled participants completed the study, 10 of 11 completers missed 5 or fewer doses, and …
Whole-body hyperthermia looks less like generic relaxation and more like a timed biological stressor: in a small depression substudy, a single session was followed by early Hamilton Depression Rating Scale improvement, heat-shock gene activation, and immune-process enrichment that included interleukin 6 production. Research Highlights Depression scores improved early: in the 18-person RNA sequencing substudy, whole-body …
A 2026 mouse study linked cholestatic liver injury to smaller thalamic volume than control injury-free mice, broad thalamus gene-expression changes, and partial pathway rescue after systemic tumor necrosis factor neutralization. Research Highlights Thalamic volume decreased: bile duct ligation (BDL; a mouse model of obstructive cholestatic liver injury) reduced thalamic volume vs. sham surgery by magnetic …