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In APP/PS1 Alzheimer's model mice, deleting PTP1B or treating with the allosteric inhibitor DPM-1003 improved memory behavior, lowered amyloid burden, and pushed microglia toward SYK-driven …
Read articleA 2026 CARDIOSA-12 secondary analysis found that active hypoglossal nerve stimulation improved sleepiness, insomnia, snoring, and sleep-related function, but objective cognitive test perform…
Read articleA 2026 Nature Communications mouse study tested 7,736 possible connections in the hippocampal CA3 memory circuit and found a developmental shift from dense early wiring toward sparse structu…
Read articleA 2026 Nature Neuroscience study from the Igarashi lab proposes a circuit-level answer for why the lateral entorhinal cortex (LEC) is the first cortical region to falter in Alzheimer’s: dopa…
Read articleDementia rates in the US, UK, Netherlands, Sweden, France, and several other high-income countries have been falling for decades, despite population aging. The standard explanation — improve…
Read articleA 2026 review in the Japanese Journal of Radiology argued that amyloid PET has moved from an optional Alzheimer’s disease biomarker to a practical eligibility gate for anti-amyloid antibody …
Read articleA 2026 humanized P301S tauopathy mouse study found that syntaxin-6 knockout partly rescued early motor impairment from months 1 to 4, protected gait at 5.5 months, reduced frailty (p = 0.005…
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