A 2026 Nature Neuroscience study found that awake mouse brain motion was driven mainly by locomotion-linked abdominal muscle activity, not by respiration or cardiac rhythm; the researchers mapped displacement vectors at 134 cortical sites in 24 mice and modeled how that motion could push fluid out of brain tissue.1 The result sharpens the body-brain mechanics …
A 2026 ADNI/A4 validation study found that Alzheimer’s plasma-biomarker machine-learning models still ranked amyloid PET status well across cohorts, but the practical rule-out number moved hard: negative predictive value fell from 0.831 inside ADNI to 0.644 when the ADNI-trained model was applied to A4.1 Research Highlights 1,707-person ADNI/A4 test: researchers trained amyloid PET prediction models …
Lecanemab blood biomarkers may rebound much faster than amyloid PET after treatment stops: a 2026 PK/PD model estimated that half of the Aβ42/40 treatment effect is lost within 0.5 years, compared with 12.1 years for amyloid PET signal.1 Research Highlights 0.5-year rebound for Aβ42/40: Bhagunde et al. estimated that half of the Aβ42/40 treatment effect …
Some sleep apnea patients stay sleepy even when their CPAP is used 6+ hours a night and apnea events have been driven back to normal range. A 2026 cross-sectional study of 65 PAP-adherent adults found those residually sleepy patients performed measurably worse on global cognition, memory, executive function, attention, and processing speed than their well-rested …
A 2026 UK Biobank analysis by Aas et al. in BMC Medicine tests the “adversity leaves a fixed biological scar” framing against five biological aging markers in 153,557 middle-aged and older adults — and the marker that moves most reliably isn’t telomere length or any metabolomic clock.1 Research Highlights 153,557-participant test: Aas et al. measured …
A 2026 medRxiv preprint found that 26 autistic children performed similarly to 25 typically developing children on objective SPACE navigation tasks, contrary to the prediction, while autistic children rated their own navigation ability lower on the Santa Barbara Sense of Direction scale.1 Research Highlights Objective performance did not separate groups: 26 autistic children and 25 …
A 2026 Human Connectome Project MRI study linked asymmetric anterior cingulate cortex sulcal pattern to lower delay discounting in 390 healthy young adults: asymmetric ACC morphology predicted a higher delay-discounting area under the curve, meaning delayed rewards lost less value.1 The finding is not a diagnostic scan for impulsivity, but it puts an early-formed cortical-folding …