A 2026 targeted metabolomics study of knee osteoarthritis found 33 altered serum metabolites and 10 altered cerebrospinal-fluid metabolites, but the symptom signal split by compartment: serum amino acids, bile acids, and acylcarnitines tracked pain or fatigue, while CSF histamine and 3-hydroxyphenylacetic acid tracked central pain and sleep measures.1 Research Highlights 33 serum metabolites shifted: knee …
A 245-person BeLOVE MRI analysis found that tissue immediately surrounding white matter hyperintensities already carried measurable injury: magnetization transfer saturation was lower inside lesions than contralesional white matter, β = −0.48, p < 0.001, and the gradient extended into normal-appearing tissue around the lesion border. The cognitive signal was narrower but clinically interesting: higher perilesional …
A 25-person pilot study of young adults found an ATP fatigue pattern that was directionally reversed from the simple “low brain energy” story: the depression group had higher visual-cortex ATP production metrics than healthy controls, while fatigue severity correlated with ATPase production rate, r = 0.73, p = 0.006.1 The cleaner interpretation is compensatory strain, …
A 2026 medRxiv preprint reported that an at-home subcallosal cingulate cortex deep brain stimulation (SCC DBS) recording system could track stable recovery in severe treatment-resistant depression: in 7 analyzable patients, the local-field-potential biomarker predicted weekly recovery states with 0.72 ± 0.16 accuracy.1 The useful claim is not that brain recordings can diagnose depression broadly; it …
A 2026 fMRI study found language and theory-of-mind activation already separated in 54 child sessions from ages 3-9, with strict child overlap near zero in the left superior temporal lobe (Dice 0.015) and no evidence that the 2 systems disentangled with age.1 The result pushes against a simple developmental story in which language grows out …
A 2026 medRxiv benchmark found Qwen3-Omni reached only moderate agreement with expert mental status examination panels: AC1 = 0.70 vs. UTHealth and 0.72 vs. Yale, below expert agreement of 0.87; its aggregate performance masked a clinical reasoning gap, overcalling visible signs such as speech and affect while missing delusions and perceptual abnormalities.1 Research Highlights Expert …
A 2026 secondary randomized-trial analysis found that low-intensity focused ultrasound and repetitive transcranial magnetic stimulation reached statistically similar 2-week post-treatment motor scores after subacute stroke, even though LIFU produced larger median Fugl–Meyer Assessment gains than rTMS: 7 vs. 2 upper-limb points and 3 vs. 1 lower-limb points.1 LIFU therefore carries the recovery-dynamics signal in this …