MentalHealthDaily

CoQ10 Preserved Working Memory in Drp1-Deficient Mice Through Coa6

by GLOOM

MHD featured image for CoQ10, working memory, Drp1 deficiency, Coa6, and mitochondrial respiratory-chain function.

A 2026 mouse study found that long-term CoQ10 exposure reduced working-memory errors in Purkinje-cell-specific Drp1-deficient mice, tying the behavioral rescue to Coa6 binding and support for mitochondrial respiratory-chain function.1 The result supports a narrow mechanistic CoQ10-Coa6 pathway under neuronal mitochondrial dysfunction while leaving human memory-supplement claims untested. Research Highlights Working memory improved in a mouse …

Single-Session tDCS Fails Working-Memory Test in Schizophrenia

by GLOOM

Stylized illustration of tDCS electrodes positioned over the right dorsolateral prefrontal cortex on a brain outline, with a pre-post working-memory task in the foreground, representing the null-result trial in schizophrenia.

Transcranial direct current stimulation (tDCS) has been pitched as a scalable cognitive-enhancement tool for schizophrenia, where roughly 98% of patients show working-memory deficits, but a 2026 sham-controlled crossover trial from Ke et al. delivered the standard 1.5 mA anodal protocol over the right DLPFC to 27 stable patients and found no detectable benefit over sham.1 …

L-Tyrosine Benefits & Unestablished Claims (Scientific Research)

by GLOOM

Tyrosine is a nonessential amino acid that was discovered circa 1846. The word “tyrosine” is derived from the Greek word “tyros” which translates roughly to “cheese.” Tyrosine is most commonly cited as “L-tyrosine” or the levorotatory “L” enantiomer due to the fact that L-amino acids are manufactured in cells and used in protein synthesis; dextrorotatory …