MentalHealthDaily

Late-Diagnosed PKU Linked to Depression in Children

by GLOOM

MHD featured image for depression and quality of life in children with phenylketonuria.

A 2026 Egyptian study of 76 children found a sharp mental-health gradient in phenylketonuria (PKU): late-diagnosed children had higher depression scores, lower quality of life, lower IQ, and a 21.4% rate of reported suicidal thoughts. Early-diagnosed children still differed from controls on some functioning measures, but the late-diagnosed group carried the heaviest psychiatric and cognitive …

Multiple Sclerosis Frailty Exercise Improved Fatigue in 6 Weeks

by GLOOM

MHD featured image for multimodal exercise, frailty, fatigue, and quality of life in multiple sclerosis.

A 2026 pilot randomized trial in 16 frail adults with multiple sclerosis found that 6 weeks of supervised multimodal exercise was feasible: retention was 87.5%, adherence was 97.2%, no adverse events were recorded, and fatigue and quality-of-life scores moved more than they did with waitlist control.1 Research Highlights Feasibility cleared the prespecified bar: 14 of …