MentalHealthDaily

PReDicT Antidepressant Algorithm Cost-Effectiveness Was Uncertain

by GLOOM

MHD featured image for PReDicT antidepressant algorithm cost-effectiveness.

A 913-person economic evaluation of the PReDicT antidepressant algorithm found nearly identical EQ-5D quality-of-life gains vs. treatment as usual (+0.139 vs. +0.140) and nearly identical societal cost reductions (−€2,589 vs. −€2,602), while cost-effectiveness probabilities were only 46% to 59% at trial level but exceeded 80% in the UK.1 The algorithm signal was country-specific and capability-weighted, …

Parkinson’s Metabolite Biomarkers Split 3 Patient Groups

by GLOOM

MHD featured image for Parkinson's disease metabolite biomarkers and patient metabolic subgroups.

A 2026 Parkinson’s disease study used gene-expression data and genome-scale metabolic modeling to predict patient-level metabolite patterns, then separated 104 patients into 3 metabolic subgroups that were partly reproduced in an independent 81-patient validation dataset. Research Highlights Patient-level modeling found heterogeneity: Abdik et al. predicted secretion tendencies for 802 analyzable metabolites across 104 postmortem substantia …