obsessive-compulsive disorder Archives

OCD DBS Reduced Y-BOCS 42.9% as GPe Alpha Activity Decreased

by GLOOM

MHD featured image for OCD DBS and GPe alpha activity.

A 2026 medRxiv preprint found that 10 severe obsessive-compulsive disorder patients treated with anterior-limb-of-internal-capsule DBS had a 42.9% average Y-BOCS symptom decrease over 6 months while alpha-band activity in the anterior globus pallidus externus fell.1 The strongest read is a response-marker signal: GPe alpha decreased during effective OCD DBS, but the sample is too small …

Rare OCD Variants in NPY5R, DLGAP1, and MAPK8IP3 Segregate in Families

by GLOOM

Editorial card for rare OCD variants in NPY5R, DLGAP1, and MAPK8IP3 across multiplex families.

A 2026 whole-genome sequencing preprint found rare variant signals in 2 multiplex obsessive-compulsive disorder (OCD) families: an NPY5R missense variant in 10 of 15 affected people in 1 pedigree, plus DLGAP1 and MAPK8IP3 signals that tracked all 3 sequenced cases in a branch of a second pedigree.1 The finding is a candidate-gene result, not a …