MentalHealthDaily

Alpha-Synuclein SAA Detected 95% of Lewy Body Dementia in ALZAN

by GLOOM

MHD featured image for alpha-synuclein SAA and Lewy body dementia biomarkers.

A 2026 ALZAN memory-clinic cohort found that cerebrospinal-fluid alpha-synuclein seed amplification assay detected 19 of 20 Lewy body dementia cases, with 95% sensitivity and 93.5% specificity against non-Lewy-body, non-Alzheimer’s controls.1 The same assay was positive in 32 of 203 Alzheimer’s disease patients, which makes the result a co-pathology warning as much as a diagnostic win. …

sCD27 Biomarker Flags Autoimmune Disease in Severe Psychiatric Disorders

by GLOOM

MHD featured image for sCD27, autoimmune disease, severe psychiatric disorders, and neuroinflammation biomarker triage.

A 2026 immunopsychiatry cohort study found that soluble CD27 (sCD27), a marker of T-cell activation, was positive in cerebrospinal fluid in 23% of severe psychiatric patients selected for suspected immune involvement and in 88% of multiple sclerosis patients used as a positive-control group. In the psychiatric cohort, combined cerebrospinal fluid or blood sCD27 positivity was …