MentalHealthDaily

Knee Osteoarthritis Pain and Fatigue Linked to Serum and CSF Metabolites

by GLOOM

MHD featured image for knee osteoarthritis pain and fatigue metabolomics.

A 2026 targeted metabolomics study of knee osteoarthritis found 33 altered serum metabolites and 10 altered cerebrospinal-fluid metabolites, but the symptom signal split by compartment: serum amino acids, bile acids, and acylcarnitines tracked pain or fatigue, while CSF histamine and 3-hydroxyphenylacetic acid tracked central pain and sleep measures.1 Research Highlights 33 serum metabolites shifted: knee …

ALS CSF Proteomics Found 399 Candidate Proteins and a 5-Protein Panel

by GLOOM

MHD featured image for ALS CSF proteomics and biomarker panels.

A 2026 cerebrospinal-fluid proteomics preprint involving 87 amyotrophic lateral sclerosis (ALS) patients, 89 healthy controls, and 61 neurological controls reported 399 ALS candidate proteins, complement markers that tracked disease stage, and a 5-protein panel that classified ALS vs. healthy controls with ROC AUC 0.95 after the best-known neurodegeneration markers were removed.1 Research Highlights CSF proteomics …