MentalHealthDaily

Low CALLY Index Predicted Mortality in Adults With Depression Symptoms

by GLOOM

MHD featured image for CALLY index, depressive symptoms, and mortality risk.

A 2026 NHANES mortality analysis found that adults with PHQ-9 depressive symptoms had lower long-term all-cause mortality when their CALLY index was higher: in the fully adjusted model, each 1-unit higher log-CALLY value carried a hazard ratio of 0.59, with a 95% confidence interval from 0.51 to 0.68.1 The useful interpretation is prognostic, not therapeutic: …

Twin Study Finds No Broad Cytokine Link to Depression or Alcohol Use Disorder

by GLOOM

Photoreal illustration of cytokine molecules and brain imagery, conveying inflammation-depression hypothesis under scrutiny.

The broad cytokine story failed its most direct community test: in 972 adults, depression, alcohol use, and alcohol use disorder (AUD) were not associated with C-reactive protein (CRP) or a pre-registered pro-inflammatory cytokine index. The only multiple-testing-corrected cytokine hits ran opposite the hypothesis — AUD was linked to lower IL-1β, IL-4, IL-10, and IL-12 — …