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Aripiprazole Oculogyric Crisis in Tourette Tics: 2 Cases at 20-30 mg

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A 2026 Neurological Sciences brief communication added 2 Tourette syndrome cases of aripiprazole-related oculogyric crisis — sustained, involuntary upward eye deviation from extraocular-muscle dystonia — after titration to 20 mg and 30 mg daily, with remission after dose reduction.1 Research Highlights 2 new Tourette cases: Cavanna et al. reported oculogyric crisis in females aged 16 …

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Knee Osteoarthritis Pain and Fatigue Linked to Serum and CSF Metabolites

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A 2026 targeted metabolomics study of knee osteoarthritis found 33 altered serum metabolites and 10 altered cerebrospinal-fluid metabolites, but the symptom signal split by compartment: serum amino acids, bile acids, and acylcarnitines tracked pain or fatigue, while CSF histamine and 3-hydroxyphenylacetic acid tracked central pain and sleep measures.1 Research Highlights 33 serum metabolites shifted: knee …

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White Matter Hyperintensity Penumbra MRI Links Hidden Damage to Cognition

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A 245-person BeLOVE MRI analysis found that tissue immediately surrounding white matter hyperintensities already carried measurable injury: magnetization transfer saturation was lower inside lesions than contralesional white matter, β = −0.48, p < 0.001, and the gradient extended into normal-appearing tissue around the lesion border. The cognitive signal was narrower but clinically interesting: higher perilesional …

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Depression Fatigue Linked to Higher ATP Brain Energy Turnover

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A 25-person pilot study of young adults found an ATP fatigue pattern that was directionally reversed from the simple “low brain energy” story: the depression group had higher visual-cortex ATP production metrics than healthy controls, while fatigue severity correlated with ATPase production rate, r = 0.73, p = 0.006.1 The cleaner interpretation is compensatory strain, …

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Bhagavad Gita and Yoga Reduced Healthcare-Worker Anxiety in 68-Person Trial

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A 68-person randomized trial in Indian healthcare workers found a narrow but useful pattern: combined yoga plus Bhagavad Gita teaching beat usual care immediately on GAD-7 anxiety scores (p = 0.009), while Gita teaching alone beat usual care at 45 days (p = 0.047).1 Yoga alone improved within its own arm, but it did not …

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Facial Palsy Telerehabilitation Reduced Anxiety in 16-Patient Pilot

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A 16-patient pilot study after facial reanimation surgery found that online emotional training and in-person emotional training both reduced anxiety and improved facial movement; FDI physical function changed by 21.25 points in the in-person group vs. 7.5 points in the online group.1 Research Highlights Small pilot, real recovery signal: Guidetti et al. followed 16 adults …

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