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Depression Linked to 12 Gastrointestinal Diseases in Genetic Analysis Study

A new study published in Translational Psychiatry found evidence that genetic predisposition to depression is associated with increased risks of 12 different gastrointestinal diseases, including irritable bowel syndrome, non-alcoholic fatty liver disease, gastroesophageal reflux disease, ulcerative colitis, and more. The study helps establish a causal relationship between depression and gastrointestinal disease risk while minimizing confounding …

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Statins & Depression: Antidepressant Effect by Lowering Cholesterol?

Statins are among the most commonly prescribed medications worldwide. While best known for lowering cholesterol, emerging evidence suggests that statin drugs may also impact mental health – but in complex, and sometimes contradictory, ways. Key Facts: Animal and some human studies show statins may have antidepressant effects by altering neurotransmitters, promoting neurogenesis, and reducing inflammation. …

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Adjunct Celecoxib for Depression & Mania: Treatment with a COX-2 Inhibitor

Celecoxib, a selective COX-2 inhibitor, shows promise as an effective and safe adjunct treatment for major depression and mania, according to a new comprehensive systematic review. The analysis also found celecoxib improved symptoms when used as a standalone antidepressant in patients with somatic disorders. However, evidence for efficacy in bipolar depression remains unclear. Key Facts: …

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Case Report: Depression Treated with Deep Brain Focused Ultrasound (2023)

Deep brain stimulation using focused ultrasound leads to rapid remission of severe depression in breakthrough patient case study. Key Facts: Focused ultrasound targeted and suppressed hyperactive areas linked to depression. Stimulation lasted just 64 minutes yet caused depression remission for over 6 weeks. Approach is noninvasive and precisely targeted with no side effects observed. Technology …

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30+ New Antidepressants (2018): Drugs In Clinical Trials

Research suggests that upwards of 16 million American adults (6.7% of the adult population) are afflicted with major depressive disorder (MDD), a neuropsychiatric condition characterized by overwhelming sadness, behavioral changes, sleep disturbances, and cognitive deficits.  As of current, depression is the leading cause of disability in the United States among individuals between the ages of …

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Niacin For Depression: Does Vitamin B3 Improve Mood?

Niacin (vitamin B3) is a colorless hydrophilic organic compound classified as an essential dietary nutrient among humans.  Foods highest in niacin include: organ meat (liver, heart, kidneys), chicken, beef, fish, venison, and whole grains.  For human adults, the daily recommended allowance of niacin falls within the range of 12 mg to 16 mg per day, …

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