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Addiction Medications in 371 Trials: No Approved Medication for Stimulant Use Disorder

MHD card showing a medication blister pack: the strongest addiction-medication evidence is for smoking and opioids; no medication is approved for stimulant use disorder.

A 2026 umbrella review of 16 systematic reviews covering 371 trials found strong medication evidence for tobacco and opioid use disorders, modest benefits for alcohol use disorder, and no approved drugs for stimulant or cannabis use disorders.1 Varenicline more than doubled smoking quit rates vs. placebo, methadone kept people in opioid treatment longer than buprenorphine, …

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Perinatal Depression in Ethiopia: 22.49% Pooled Umbrella Prevalence

MHD featured image for perinatal depression prevalence in Ethiopia.

An Ethiopian umbrella review estimated perinatal depressive symptoms at 22.49% across 8 systematic reviews and meta-analyses. Antenatal and postnatal rates were similar, so the burden spans the whole perinatal window rather than clustering only after delivery.1 Research Highlights Overall pooled prevalence was 22.49%: Necho et al. combined 8 Ethiopian systematic reviews and meta-analyses covering 28 …

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