Chronic Pain Plus Depression Alters Brain Structure
A 2026 UK Biobank MRI preprint involving 71,214 adults found that chronic pain plus current depression had a structural brain profile that was more than chronic pain plus depression pasted together. The 1,377-person comorbid group showed widespread lower cortical volume, lower bilateral thalamic and hippocampal volume, lower left accumbens volume, and broad white-matter microstructure differences …