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Subthreshold Depression Linked to Inflammation and Altered Brain Connectivity

MHD card showing a side-view brain with a glowing crimson cingulate arc and a blood vessel releasing small red particles, illustrating a study in which university students with subthreshold depression had altered brain connectivity and slightly higher inflammatory proteins.

University students with subthreshold depression, meaning real depressive symptoms that fall short of a major depression diagnosis, had stronger connections in 3 cingulate brain circuits and slightly higher levels of 3 inflammatory proteins than healthy students, according to a 2026 brain-imaging study from China.1 Research Highlights Stronger cingulate connections: resting brain scans of 126 students …

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Online MBCT for Cancer Distress: 9-Month Trial Data

MHD featured image for online mindfulness-based cognitive therapy and cancer-related distress.

A 2026 analysis followed 161 people with cancer for 9 months to evaluate whether 2 forms of online mindfulness-based cognitive therapy reduced psychological distress: therapist-led group-blended care and individual self-guided modules. Psychological distress improved significantly in both formats, but fewer participants dropped out when the program included therapist-led group sessions. Research Highlights Distress improved through …

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