MentalHealthDaily

Prior Cocaine Use Disrupts Orbitofrontal Hidden-State Coding

by GLOOM

A 2026 eLife study recorded 3,881 lateral orbitofrontal cortex units in rats and found that prior cocaine use made the OFC over-distinguish task positions that controls treated as functionally equivalent. The headline result was not gross task failure: cocaine-experienced rats still performed the odor task, but their OFC ensembles showed higher S1-vs.-S2 decoding than sucrose …

PTSD With Depression Hits AMPA Receptors Harder in Rat Models

by GLOOM

Photoreal illustration of synaptic AMPA receptors and stressed neuron, conveying glutamate-system dysregulation in PTSD-MDD comorbidity.

PTSD and major depressive disorder co-occur in roughly half of patients with either diagnosis, and the comorbid presentation is more severe than either alone. The mechanistic question has been whether comorbidity reflects synergistic biology or simple symptom additivity. A 2026 rat-model study by Jiang and colleagues tests this directly, finding that PTSD-MDD comorbid rats show …