Celecoxib for Depression: 7 Trials, Add-On Benefit Unclear
A 7-trial review favored adding celecoxib to antidepressants for depression, but its benefit was not confirmed after 3 high-risk trials were excluded.
randomized trials
Ultrasound-Guided Acupotomy Reduced Chronic Spinal Pain in 32 RCTs
A 2026 meta-analysis of 32 randomized trials involving 2,669 participants found that ultrasound-guided acupotomy reduced chronic spinal musculoskeletal pain, with pain intensity improving by SMD = −0.80 and disability by SMD = −0.99 on NDI/ODI measures.1 The direction is favorable, but all trials came from China and evidence certainty stayed moderate for pain and low …