randomized crossover trial Archives

150 mg Caffeine Did Not Trigger Panic in Panic Disorder Trial

by GLOOM

MHD featured image for caffeine and panic disorder challenge research.

A randomized crossover trial found that 150 mg caffeine did not increase subjective anxiety, interoceptive attention, or anxiety from body sensations in 29 people with panic disorder compared with 53 healthy controls.1 The result runs opposite the hypothesis, but it does not make caffeine inert: caffeine still increased physiological arousal, costly avoidance, and attention problems …

Extra-Virgin Olive Oil Raised Brain Connectivity in a 9-Person Pilot

by GLOOM

MHD featured image for extra-virgin olive oil and brain connectivity.

A 9-person randomized crossover neuroimaging substudy found that high-polyphenol extra-virgin olive oil increased occipital resting-state functional connectivity compared with regular olive oil, beta = 0.20, 95% CI 0.03 to 0.37, p = 0.016.1 The result is a measurable brain-signal finding, but the clinical claim stays small: connectivity changed, cognition was not the endpoint. Research Highlights …