MentalHealthDaily

Household Pesticide 3-PBA Linked to Depression Risk in 6,502 Adults

by GLOOM

MHD featured image for household pesticide biomarkers and depression risk.

A 2026 NHANES analysis of 6,502 adults found that urinary 3-PBA, a pyrethroid insecticide metabolite, was modestly associated with depression risk at OR = 1.02 per 1 μg/L, while self-reported household pesticide exposure weakened after full adjustment to OR = 1.43 (95% CI 0.91 to 2.25).1 The calibrated read is biomarker signal first, causal language …

Low CALLY Index Predicted Mortality in Adults With Depression Symptoms

by GLOOM

MHD featured image for CALLY index, depressive symptoms, and mortality risk.

A 2026 NHANES mortality analysis found that adults with PHQ-9 depressive symptoms had lower long-term all-cause mortality when their CALLY index was higher: in the fully adjusted model, each 1-unit higher log-CALLY value carried a hazard ratio of 0.59, with a 95% confidence interval from 0.51 to 0.68.1 The useful interpretation is prognostic, not therapeutic: …