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Masitinib for ALS: AB10015 Reports 42.3% 5-Year Survival

MHD featured image for masitinib, ALS survival, and AB10015 long-term follow-up.

A 2026 AB10015 post-hoc preprint reported 42.3% 5-year survival from amyotrophic lateral sclerosis symptom onset among patients originally assigned to masitinib 4.5 mg/kg/day with riluzole. The number is large for ALS, but the long-term comparison is historical and modeled rather than randomized placebo follow-up.1 Research Highlights 42.3% reached 5 years from onset: Ludolph et al. …

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ALS Entropy Analysis Finds 5-Month Signal Hidden by ALSFRS Scores

MHD featured image for ALS trial endpoints, Shannon entropy, and ALSFRS domain trajectories.

A 2026 PRO-ACT analysis of amyotrophic lateral sclerosis (ALS) trial data found a signal that ordinary ALSFRS total-score slopes cannot even express: Shannon entropy trajectories diverged between pooled active and placebo arms, including a 5-month delay in peak Fine Motor distributional spread for active-arm patients.1 Research Highlights Entropy found an endpoint-level signal: Rodriguez analyzed 7,512 …

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