MentalHealthDaily

Parcel-Guided rTMS for Treatment-Resistant Depression: 6 of 11 Remitted in Pilot

by GLOOM

MHD card showing a dark violet mosaic of irregular brain-atlas parcels, with three highlighted parcels meeting at a glowing crosshair target beneath a figure-eight TMS coil, illustrating parcel-guided rTMS for treatment-resistant depression.

Researchers aimed repetitive transcranial magnetic stimulation (rTMS), which uses magnetic pulses to stimulate brain cells, at a spot chosen from each person’s own brain scan. In a small Columbia University pilot, 6 of 11 adults with treatment-resistant depression ended with low depression scores that met the trial’s remission threshold.1 Research Highlights Symptoms improved at the …

Music During Ketamine Did Not Improve Resistant Depression

by GLOOM

MHD featured image for ketamine psychotherapy, treatment-resistant depression, music, and psychedelic-like treatment context.

Adding music to ketamine psychotherapy failed to provide extra antidepressant benefit over matched non-music support in a 2026 randomized clinical trial (RCT; a study that assigns participants to groups by chance), even though the full 6-infusion ketamine-psychotherapy course was followed by large depression-score reductions. Research Highlights Music added no confirmed MADRS benefit: in the MUSIK …