MentalHealthDaily

DNA Methylation Biological Age Slope Raised Mortality Risk 28%

by GLOOM

MHD featured image for DNA methylation biological age and mortality risk.

A 2026 Clinical Epigenetics study tracked DNA methylation biological age in 894 older adults and found that each 1-SD higher biological-age slope predicted 17-28% higher all-cause mortality risk across 5 epigenetic clocks.1 The clocks moved more slowly than calendar time over 8.1 years, but participants with higher methylation-age slopes had worse survival than participants with …

Neighborhood Deprivation Linked to Faster Epigenetic Aging in 370 Adults

by GLOOM

Editorial card showing neighborhood deprivation, lifetime adversity, and epigenetic clock acceleration.

A 2026 medRxiv preprint involving 370 healthy adults found that each increase in neighborhood-deprivation percentile rank was associated with epigenetic age acceleration on 3 of 4 second-generation DNA-methylation clocks, with lifetime adversity explaining 20.3% of the GrimAge association and 23.3% of the PCGrimAge association.1 Research Highlights 3 of 4 clocks accelerated: each increase in Area …