MentalHealthDaily

Alzheimer’s Fingerprick Blood Biomarkers: p-tau217 and GFAP Track Cognition

by GLOOM

MHD featured image for Alzheimer’s disease fingerprick blood biomarkers p-tau217 and GFAP.

A 2026 PROTECT study involving 174 older adults found that self-administered fingerprick p-tau217 correlated with episodic memory (r = 0.299, p < 0.001) and GFAP correlated with working memory (r = 0.183, p = 0.034), supporting remote Alzheimer's risk triage rather than a stand-alone dementia diagnosis. Research Highlights Fingerprick sampling reached 77% completion: 174 of …

Lecanemab Blood Biomarkers Rebound Faster Than Amyloid PET After Stopping

by GLOOM

Editorial card showing lecanemab maintenance dosing and Alzheimer's blood biomarkers with blood vials, amyloid PET imagery, and biomarker trajectory lines.

Lecanemab blood biomarkers may rebound much faster than amyloid PET after treatment stops: a 2026 PK/PD model estimated that half of the Aβ42/40 treatment effect is lost within 0.5 years, compared with 12.1 years for amyloid PET signal.1 Research Highlights 0.5-year rebound for Aβ42/40: Bhagunde et al. estimated that half of the Aβ42/40 treatment effect …