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Parkinson’s Brain-Heart Coupling Signals MMSE and Freezing of Gait

MHD featured image for Parkinson's brain-heart coupling and freezing of gait.

A 2026 EEG-ECG preprint reported that beta efficiency-sympathetic coupling differed across healthy young adults, healthy older adults, and Parkinson’s disease patients, p = 0.0032, while gamma efficiency-sympathetic coupling differed at p = 0.0003.1 The main claim is that motor, cognitive, and autonomic physiology may be coupled tightly enough to deserve biomarker-level study. Research Highlights Brain-heart …

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Resting HRV Sex Difference Detected in 2-5 Second Fluctuations

MHD featured image for resting heart rate variability, sex differences, and autonomic regulation.

A 2026 ECG analysis involving 269 healthy young adults found that sex differences in resting heart-rate dynamics appeared in very short 2-5 second fluctuations, not in the usual 5-minute heart rate variability averages. The short-window similarity graph metric predicted male sex with an odds ratio of 2.78 (95% CI 1.32-5.86), while conventional lnRMSSD, lnHF-HRV, and …

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