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Parcel-Guided rTMS for Treatment-Resistant Depression: 6 of 11 Remitted in Pilot

MHD card showing a dark violet mosaic of irregular brain-atlas parcels, with three highlighted parcels meeting at a glowing crosshair target beneath a figure-eight TMS coil, illustrating parcel-guided rTMS for treatment-resistant depression.

Researchers aimed repetitive transcranial magnetic stimulation (rTMS), which uses magnetic pulses to stimulate brain cells, at a spot chosen from each person’s own brain scan. In a small Columbia University pilot, 6 of 11 adults with treatment-resistant depression ended with low depression scores that met the trial’s remission threshold.1  Research Highlights Symptoms improved at the …

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tDCS for Empathy: rTPJ Increased Other-Pain Signals, DLPFC Did Not

MHD featured image for tDCS empathy and rTPJ versus DLPFC social cognition.

A 2026 Psychological Medicine study involving 196 healthy adults found that transcranial direct current stimulation over the right temporoparietal junction increased cognitive empathy signals across pain and video tasks, while left dorsolateral prefrontal cortex stimulation produced narrower and less consistent effects.1 The useful finding is anatomical calibration: rTPJ looked more like an other-state representation target, …

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tDCS of the DLPFC Treats Anhedonia in Depression & Improves Social Functioning (2024 Study)

In the quest to find more effective treatments for depression, particularly the challenging symptom of anhedonia, Transcranial Direct Current Stimulation (tDCS) emerges as a promising option. This non-invasive brain stimulation technique targets specific brain regions to modulate activity and potentially alleviate symptoms. A recent study has shed light on the efficacy and safety of targeting …

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