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Ebselen Failed to Reduce Impulsivity in 130 Healthy Adults

MHD featured image for ebselen and impulsivity placebo trial.

A double-blind placebo-controlled trial found no evidence that ebselen reduced impulsivity in 130 healthy adults: 66 received ebselen, 64 received placebo, and the 1,800 mg 2-day regimen did not improve motor impulsivity, reflection impulsivity, or delay discounting.1 The more interesting calibration is that several trait-impulsivity interactions ran opposite the secondary prediction, weakening the idea that …

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Anterior Cingulate Sulcus Asymmetry Linked to Lower Delay Discounting

MHD featured image for anterior cingulate sulcus asymmetry and delay discounting.

A 2026 Human Connectome Project MRI study linked asymmetric anterior cingulate cortex sulcal pattern to lower delay discounting in 390 healthy young adults: asymmetric ACC morphology predicted a higher delay-discounting area under the curve, meaning delayed rewards lost less value.1 The finding is not a diagnostic scan for impulsivity, but it puts an early-formed cortical-folding …

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