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Parkinson’s Brain-Heart Coupling Signals MMSE and Freezing of Gait

MHD featured image for Parkinson's brain-heart coupling and freezing of gait.

A 2026 EEG-ECG preprint reported that beta efficiency-sympathetic coupling differed across healthy young adults, healthy older adults, and Parkinson’s disease patients, p = 0.0032, while gamma efficiency-sympathetic coupling differed at p = 0.0003.1 The main claim is that motor, cognitive, and autonomic physiology may be coupled tightly enough to deserve biomarker-level study. Research Highlights Brain-heart …

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Multiple System Atrophy nOH: 41.7% Diagnosed, 40.0% Suspicious

MHD featured image for multiple system atrophy nOH burden and blood pressure screening.

A 259-person multiple system atrophy survey found diagnosed neurogenic orthostatic hypotension in 41.7% of respondents, while another 40.0% had upright symptoms suspicious for nOH without a diagnosis and 21.2% reported never having upright blood pressure measured.1 The operational problem is simple: in MSA, low blood pressure on standing can be disabling, missed, and still undertreated …

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Pulse-Wave Harmonics Flag MCI During Cognitive Stress: 2.6-Point Gap

MHD featured image for pulse-wave harmonic coherence, cognitive stress, and mild cognitive impairment screening.

A 2026 community study of 101 older adults found that pulse-wave harmonics changed in a more organized way during a subtraction task in cognitively intact participants than in people with MoCA-defined mild cognitive impairment: amplitude-coherence scores averaged 9.00 vs. 6.40, a 2.60-point gap on a 0-10 scale. Research Highlights Cognitive stress exposed the signal: resting …

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