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Early Clozapine in Schizophrenia: 34% Lower Relapse Risk

Stylized illustration of a stopwatch overlaying schizophrenia treatment-stage icons, representing the multi-year delay before clozapine is offered to patients who already meet treatment-resistance criteria.

Clozapine has been the most effective antipsychotic in schizophrenia for almost 40 years, yet it is still routinely held back until patients have failed multiple alternatives over many years — a “third-line, after years of failure” default that a 2026 Current Opinion review by Davani et al. argues is no longer supported by the evidence.1 …

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Music During Ketamine Did Not Improve Resistant Depression

MHD featured image for ketamine psychotherapy, treatment-resistant depression, music, and psychedelic-like treatment context.

Adding music to ketamine psychotherapy failed to provide extra antidepressant benefit over matched non-music support in a 2026 randomized clinical trial (RCT; a study that assigns participants to groups by chance), even though the full 6-infusion ketamine-psychotherapy course was followed by large depression-score reductions. Research Highlights Music added no confirmed MADRS benefit: in the MUSIK …

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Complex PTSD Therapy Helped Affect Regulation Most

A 2026 systematic review and meta-analysis of randomized trials found no broad superiority for phase-based complex PTSD care across most outcomes. Affect dysregulation was the clearest exception, improving more when treatment was phase-based, multi-phase, and exposure-containing. Research Highlights Most therapy formats helped: across waitlist and treatment-as-usual comparisons, psychological interventions reduced PTSD symptoms (k = 9; …

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Social Media Abstinence Failed to Improve Well-Being

Editorial card showing a muted social media feed beside a calm offline space, emphasizing that abstinence did not reliably improve well-being.

A 2025 preregistered meta-analysis found that temporary social media abstinence did not significantly improve positive affect, negative affect, or life satisfaction across 10 adult experiments involving 4,674 participants.1 The result does not prove that every break is useless, but it challenges the generic “digital detox” claim that simply logging off reliably improves mood. Research Highlights …

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