white matter hyperintensities Archives

Small-Vessel Disease MRI Score Predicted 90-Day Cognition After Stroke

by GLOOM

MHD featured image for composite small-vessel disease MRI and post-stroke cognitive recovery.

A 2026 medRxiv preprint involving 65 early subacute stroke survivors found that a composite cerebral small-vessel disease MRI score predicted 90-day cognitive recovery more reliably than any single input marker.1 Lower baseline burden predicted higher follow-up Montreal Cognitive Assessment scores (β = −0.19; p = 0.009) and remained associated after baseline cognition was included (β …

White Matter Hyperintensity Penumbra MRI Links Hidden Damage to Cognition

by GLOOM

MHD featured image for white matter hyperintensity penumbra MRI and cognition.

A 245-person BeLOVE MRI analysis found that tissue immediately surrounding white matter hyperintensities already carried measurable injury: magnetization transfer saturation was lower inside lesions than contralesional white matter, β = −0.48, p < 0.001, and the gradient extended into normal-appearing tissue around the lesion border. The cognitive signal was narrower but clinically interesting: higher perilesional …