vascular cognitive impairment Archives

Post-Stroke Aphasia Theory of Mind Linked to Cerebral Microbleeds

by GLOOM

MHD featured image for post-stroke aphasia, theory of mind, and cerebral microbleeds.

A 2026 medRxiv preprint involving 44 people with chronic post-stroke aphasia found reduced performance on nonverbal false-belief tasks in 23% of participants on the Reality-Unknown task and 36% on the Reality-Known task, with accuracy tied more clearly to cerebral microbleed burden than to aphasia severity.1 The result reframes social-cognitive testing after stroke as a vascular …

White Matter Hyperintensity Penumbra MRI Links Hidden Damage to Cognition

by GLOOM

MHD featured image for white matter hyperintensity penumbra MRI and cognition.

A 245-person BeLOVE MRI analysis found that tissue immediately surrounding white matter hyperintensities already carried measurable injury: magnetization transfer saturation was lower inside lesions than contralesional white matter, β = −0.48, p < 0.001, and the gradient extended into normal-appearing tissue around the lesion border. The cognitive signal was narrower but clinically interesting: higher perilesional …