hit counter

Group fMRI Misread Cognitive Control in 4,423 Youth

MHD featured image for group fMRI and individual cognitive-control brain signals.

A 2026 ABCD stop-signal fMRI study found that group-level cognitive-control brain signals often failed to describe within-person brain dynamics: across 16 comparisons, between-person and within-person associations diverged, and several reversed direction.1 The practical warning is narrow but sharp: a brain pattern that separates people in a group may be the wrong map for explaining how …

Read more

ALS Entropy Analysis Finds 5-Month Signal Hidden by ALSFRS Scores

MHD featured image for ALS trial endpoints, Shannon entropy, and ALSFRS domain trajectories.

A 2026 PRO-ACT analysis of amyotrophic lateral sclerosis (ALS) trial data found a signal that ordinary ALSFRS total-score slopes cannot even express: Shannon entropy trajectories diverged between pooled active and placebo arms, including a 5-month delay in peak Fine Motor distributional spread for active-arm patients.1 Research Highlights Entropy found an endpoint-level signal: Rodriguez analyzed 7,512 …

Read more