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Single-Session tDCS Fails Working-Memory Test in Schizophrenia

Stylized illustration of tDCS electrodes positioned over the right dorsolateral prefrontal cortex on a brain outline, with a pre-post working-memory task in the foreground, representing the null-result trial in schizophrenia.

Transcranial direct current stimulation (tDCS) has been pitched as a scalable cognitive-enhancement tool for schizophrenia, where roughly 98% of patients show working-memory deficits, but a 2026 sham-controlled crossover trial from Ke et al. delivered the standard 1.5 mA anodal protocol over the right DLPFC to 27 stable patients and found no detectable benefit over sham.1 …

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