REM sleep behavior disorder Archives

Parkinson’s Disease Prevention: Prodromal Symptoms, RBD, Early Intervention Trials

by GLOOM

Photoreal illustration of a brain with prodromal pathology and a clock indicating early-window intervention opportunity for Parkinson's prevention.

Parkinson’s disease has a years-to-decades prodromal stage where motor symptoms haven’t yet emerged but pathology is accumulating. A 2026 review by Schaeffer et al. synthesizes the case for (and limits of) intervening during this window — with implications for high-risk individuals weighing whether to enter preventive trials.1 Research Highlights Prodromal Parkinson’s disease is the period …

Lewy Body Dementia Cognitive Fluctuations Affect 75-90% of Patients

by GLOOM

Photoreal illustration of fluctuating brain activity overlay on an older adult, conveying alertness variability characteristic of DLB.

Cognitive fluctuations are a defining feature of dementia with Lewy bodies (DLB), helping distinguish it from Alzheimer’s disease — but they remain notoriously difficult to characterize and measure. A 2026 review by Mahajan and colleagues maps the neurobiology, measurement, and clinical implications of fluctuations across the Lewy body spectrum.1 Research Highlights Cognitive fluctuations are episodes …