MentalHealthDaily

Olfactory MRI Radiomics Link pTau217 to Alzheimer’s Cognition

by GLOOM

MHD featured image for olfactory MRI radiomics, pTau217, and Alzheimer's disease cognitive impairment.

A 2026 multi-cohort Alzheimer’s disease study found that MRI radiomics from the hippocampus and amygdala linked plasma pTau217 and smell identification to cognitive impairment — with more added cognitive signal than simple regional volume. The result is useful because it points to a possible bridge between blood biomarkers and brain-circuit damage, but it is still …

Tau Oligomers Disrupted Nuclear Lamina in Alzheimer’s Disease Models

by GLOOM

MHD featured image for tau oligomers, nuclear lamina disruption, and Alzheimer's disease models.

A 2026 Acta Neuropathologica study found that oligomeric tau was linked to early nuclear lamina disruption in Alzheimer’s disease tissue, PS19 tauopathy mice, and human induced pluripotent stem cell (iPSC)-derived neurons.1 The strongest claim is mechanistic: tau oligomers appeared to deform the nuclear envelope and disturb chromatin before overt neurodegeneration, but the work does not …