psychiatric biomarkers Archives

Psychiatric Brain Biomarkers Lack Clinical Use: 441-Study Map

by GLOOM

Psychiatric brain biomarkers have produced a large research literature but little routine clinical use. A 2026 evidence map found 441 primary studies and 27 systematic reviews of neuroimaging or neurophysiologic biomarkers for mental-health disorders, yet the field still looks too small, cross-sectional, and depression-heavy for ordinary diagnostic or treatment decisions.1 Research Highlights Large map, weak …

Early Mental Illness Severity Tracks Genetics and Brain Volume in PRONIA

by GLOOM

MHD featured image for transdiagnostic early mental illness severity, genetics, and brain volume.

A 2026 PRONIA preprint involving 727 discovery-sample participants found that early mental illness severity cut across psychosis risk, recent psychosis, and recent depression: groups with higher symptom severity also had poorer functioning, higher schizophrenia and depression polygenic risk, and lower gray matter volume. Research Highlights Severity crossed diagnostic labels: Ye et al. stratified 727 participants …