prelimbic cortex

Published research on prelimbic cortex.

AddictionJul 7, 2026

Cocaine-Alcohol Relapse Shifts Prelimbic-Accumbens Circuit

Cocaine relapse circuitry looks different when alcohol is part of the history. In a rat model, inhibiting prelimbic cortex neurons projecting to the nucleus accumbens core blocked cue-trigge…

Read article →

DepressionJun 28, 2026

Environmental Enrichment Reversed Visceral Pain and Depression in Rats

A 2026 Communications Biology rat study found that enriched housing reversed early-life-stress visceral hypersensitivity and depression-like behavior by normalizing a CB1 receptor-linked pre…

Read article →

DrugsJan 16, 2024

KNT-127 for Anxiety: Delta Opioid Receptor Agonist via PL-BLA Pathway (2023 Study)

Recent scientific advancements have illuminated the crucial role of the prelimbic cortex to basolateral amygdala (PL-BLA) pathway in regulating anxiety-like behaviors. Utilizing cutting-edge…

Read article →