Environmental Enrichment Reversed Visceral Pain and Depression in Rats
A 2026 Communications Biology rat study found that enriched housing reversed early-life-stress visceral hypersensitivity and depression-like behavior by normalizing a CB1 receptor-linked prefrontal-limbic circuit connecting prelimbic cortex, anteroventral bed nucleus of the stria terminalis, and paraventricular hypothalamus.1 Huang et al. mapped a gut-pain and mood circuit in rats, but the experiment does not prove that …
