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NeuroMark SPECT Found 23 Schizophrenia Perfusion Network Changes

MHD featured image for NeuroMark SPECT schizophrenia perfusion-network research.

A 2026 medRxiv preprint built a reusable NeuroMark SPECT template from 2 large independent component analysis rounds, then applied it to 137 schizophrenia patients and 76 controls; after false-discovery-rate correction, 23 of 68 perfusion components differed between groups.1 Those data support infrastructure for comparing SPECT perfusion networks across datasets, with standalone schizophrenia diagnosis left outside …

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Depression SPECT Study Links Worry to NeuroMark Brain Networks

MHD featured image for NeuroMark SPECT and depression biomarkers.

A 2026 medRxiv preprint used 68 NeuroMark SPECT components to analyze 2,746 psychiatric patient scans and 76 controls, linking depression-related worry/rumination and social disinterest to brain-network patterns.1 This preprint is useful as a large biomarker-generating map, but the clinical-diagnostic claim needs much more caution than the sample size alone suggests. Research Highlights Large clinical SPECT …

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